Here is a list of all of Tom Petty and the Heartbreakers' appearances on Saturday Night Live.
| Season | Episode | Date | Episode Host | Songs Performed | Notes |
| #5 ('79-'80) | #95 | November 10, 1979 | Buck Henry | "Refugee" & "Don't Do Me Like That" | TP&HB's first SNL appearance. |
| #8 ('82-'83) | #152 | February 19, 1983 | Howard Hesseman | "The Waiting" & "Change of Heart" | |
| #14 ('88-'89) | #266 | May 20, 1989 | Steve Martin | "Runnin' Down a Dream" & "Free Fallin'" | |
| #17 ('91-'92) | #309 | October 12, 1991 | Kirstie Alley | "Into the Great Wide Open" & "King's Highway" | |
| #20 ('94-'95) | #372 | November 19, 1994 | John Turturro | "You Don't Know How It Feels" & "Honey Bee" | Dave Grohl on drums. |
| #22 ('96-'97) | #407 | September 28, 1996 | Tom Hanks | "Walls (No. 3)" & "Angel Dream (No. 2)" | Curt Bisquera on drums |
| #24 ('98-'99) | #463 | April 10, 1999 | John Goodman | "Swingin'" & "Room at the Top" | |
| #35 ('09-'10) | #680 | May 15, 2010 | Alec Baldwin | "I Should Have Known It" & "Jefferson Jericho Blues" | TP also in the SNL Digital Short. |